Genetic studies in rheumatoid arthritis

Genetic studies in Rheumatoid Arthritis

Genetic studies of rheumatoid arthritis

Rheumatoid arthritis (RA) is a common autoimmune disease that results in significant morbidity. As with other complex disorders, genome-wide association studies (GWASs) have greatly contributed to the current understanding of RA etiology. In this review, we describe the genetic configuration of RA as revealed primarily through GWASs and their meta-analyses. In addition, we discuss the pathologi...

Comparing bone mineral density in rheumatoid arthritis and psoriatic arthritis

Background: Changes in patients’ bone mineral density (BMD) is one of the problems in patients with rheumatoid arthritis, which can be due to the use of corticosteroid drugs to reduce patients' symptoms or due to the aging process in patients. In this study, we decided to compare BMD in patients with psoriatic arthritis and rheumatoid arthritis. Methods: This study as a cross-sectional descrip...

Genetic Studies of Rheumatoid Arthritis: Progress and Challenges

pISSN: 2093-940X, eISSN: 2233-4718 Copyright c 2015 by The Korean College of Rheumatology. All rights reserved. This is a Free Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited. Review Article Journal of Rheumatic Diseases Vol. 22, No. 5, October, 2015 http://dx.doi.org/10.4078/jrd.2015.22.5.274

ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODI ES IN RHEUMATOID ARTHRITIS

Antineutrophil cytoplasmic autoantibodies (ANCA) were detected in patients with autoimmune and vascular diseases such as Wegener's granulomatosis, polyarteritis nodosa and systemic lupus erythematosus. Indirect immunofluorescence (IIF) technique was employed to detect these autoantibodies. By this method, two general patterns of ANCA were seen: a cytoplasmic (cANCA) and a perinuclear form ...